Study of Gut Microbiota and Lung Complications in Elderly Patients Undergoing Planned Upper Abdominal Surgery

What this Trial Is About

Researchers are examining the relationship between the composition of preoperative oropharyngeal and gut microbiota and the occurrence of postoperative pulmonary complications PPCs in elderly patients undergoing elective upper abdominal surgery. This study uses both retrospective and prospective cohort methods to analyze how microbial and metabolite levels before surgery may relate to complications like pneumonia, atelectasis, and hypoxemia within 7 days after surgery. The study involves elderly patients aged 65 and older who are scheduled for elective upper abdominal surgery lasting more than 2 hours under general anesthesia with tracheal intubation. Researchers collect preoperative oropharyngeal and fecal samples, as well as plasma, for microbial sequencing and untargeted metabolomics analysis. Participants are grouped based on whether they experience PPCs after surgery PPC positive or negative groups. Participants will be monitored for PPCs within the first 7 days after surgery. Blood samples are taken before and within 7 days post-surgery to measure inflammatory cells and cytokine levels. The study aims to gather detailed data on how microbiota and inflammation markers relate to pulmonary complications, with the overall participation continuing as patients undergo surgery and post-surgical monitoring.

Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients