Actively Recruiting
Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
Led by Peking Union Medical College Hospital · Updated on 2025-02-28
100
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study adopts a combination of retrospective and prospective cohort research methods to explore the composition of preoperative oropharyngeal and gut microbiota in elderly patients undergoing elective upper abdominal surgery, aiming to analyze the correlation between preoperative oropharyngeal and intestinal microbiota composition and metabolite levels and the occurrence of postoperative pulmonary complications (PPCs). The research subjects of the retrospective cohort study were participants (ClinicalTrials.gov No. NCT05679661) included in the prospective RCT on the effects of perioperative immune nutrition intervention and oral hygiene on postoperative complications in elderly patients, which was conducted at Peking Union Medical College Hospital from January 2023 to present. The prospective cohort study plans to continue enrolling elderly patients aged ≥ 65 who underwent elective upper abdominal surgery. This study collects preoperative oropharyngeal and fecal samples, as well as preoperative plasma from patients for microbial sequencing and untargeted metabolomics analysis. The main outcome measurement is PPCs, which include pneumonia, atelectasis, and hypoxemia within 7 days after surgery. Inflammatory cells and cytokines in peripheral blood are secondary outcomes.
CONDITIONS
Official Title
Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Scheduled for upper abdominal surgery expected to last 2 hours or more
- Surgery performed under general anesthesia with tracheal intubation
- ASA classification I to IV
- Moderate to high risk of postoperative pulmonary complications according to ARISCAT score
- Ability to understand the study and provide written informed consent, or have a family member who can
You will not qualify if you...
- Emergency surgery
- Second surgery within the past month
- Preexisting pulmonary infection or serious lung complications before surgery
- Use of antibiotics, probiotics, or acid suppressants within one month before surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Anesthesiology, Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
Research Team
Q
Qianmei Zhu
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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