Actively Recruiting
Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
Led by Peking Union Medical College Hospital · Updated on 2025-02-28
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are examining the relationship between the composition of preoperative oropharyngeal and gut microbiota and the occurrence of postoperative pulmonary complications (PPCs) in elderly patients undergoing elective upper abdominal surgery. This study uses both retrospective and prospective cohort methods to analyze how microbial and metabolite levels before surgery may relate to complications like pneumonia, atelectasis, and hypoxemia within 7 days after surgery. The study involves elderly patients aged 65 and older who are scheduled for elective upper abdominal surgery lasting more than 2 hours under general anesthesia with tracheal intubation. Researchers collect preoperative oropharyngeal and fecal samples, as well as plasma, for microbial sequencing and untargeted metabolomics analysis. Participants are grouped based on whether they experience PPCs after surgery (PPC positive or negative groups). Participants will be monitored for PPCs within the first 7 days after surgery. Blood samples are taken before and within 7 days post-surgery to measure inflammatory cells and cytokine levels. The study aims to gather detailed data on how microbiota and inflammation markers relate to pulmonary complications, with the overall participation continuing as patients undergo surgery and post-surgical monitoring.
CONDITIONS
Brief Title
Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Scheduled for elective upper abdominal surgery expected to last at least 2 hours
- Planned general anesthesia with tracheal intubation
- ASA physical status classification I to IV
- Medium to high risk of postoperative pulmonary complications as assessed by ARISCAT score
- Ability to understand the study and provide written informed consent
You will not qualify if you...
- Emergency surgery
- Second surgery within the past month
- Presence of pulmonary infection or serious lung complications before surgery
- Use of antibiotics, probiotics, or acid suppressants within one month before surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and up to 7 days after surgery
Participants undergo elective upper abdominal surgery lasting at least 2 hours and receive immediate post-operative care.
Assessments before surgery and daily visits up to 7 days post-surgery
Trial Site Locations
Total: 1 location
1
Department of Anesthesiology, Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
Research Team
Q
Qianmei Zhu
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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