Genetic Study to Find Factors Predicting Success of Mediterranean and Low-FODMAP Diets for Treating Irritable Bowel Syndrome IBS Symptoms

What this Trial Is About

Researchers are investigating genetic factors that may influence how patients with Irritable Bowel Syndrome IBS respond to a special combined diet which includes a Mediterranean diet and a low-FODMAP diet. This study focuses on identifying single nucleotide polymorphisms SNPs linked to positive or negative diet responses. IBS is a common chronic digestive disorder affected by many factors including genetics, and this study aims to understand the genetic role in dietary treatment success. Participants will follow a three-phase dietary intervention starting with an elimination phase on the Med-LFD diet for 2 to 6 weeks. This is followed by a gradual reintroduction of foods high in FODMAPs over 6 to 8 weeks to test personal tolerance, and finally a maintenance phase where an individualized diet is tailored based on that tolerance. Blood and stool samples will be collected before and after the intervention for DNA and gut microbiota analysis. Throughout the study, symptom severity will be measured using the IBS-SSS scale, and mental health assessed with the Hospital Anxiety and Depression Scale HADS. Researchers will also evaluate quality of life, symptom burden, and changes in gut microbiota from baseline through about one year of follow-up. Participants will be asked to commit to availability during the study period, and the main outcome is finding genetic markers linked to diet response.

GWAS to Identify Predictive Genetic Factors for the Success of Dietary Intervention in the Treatment of IBS Symptoms