Study of N-Acetyl Cysteine NAC Effects on Oxidative Stress in Veterans with Gulf War Illness Aged 47 to 70

What this Trial Is About

Researchers are investigating whether N-Acetyl Cysteine NAC can reduce chronic oxidative stress and restore antioxidant levels in veterans with Gulf War Illness GWI. This study focuses on understanding how NAC affects mitochondrial function and oxidative stress in the central nervous system CNS, which are believed to contribute to the symptoms of GWI such as fatigue, pain, and neurological issues. The study is an early-phase, randomized, placebo-controlled trial aimed at exploring NACs impact on serum glutathione levels and CNS oxidative stress. Participants will be randomly assigned to receive either NAC 900 mg twice daily or a matching placebo for 8 weeks. The intervention is designed to assess NACs ability to target mitochondrial dysfunction and oxidative stress compared to placebo. The study includes a follow-up period extending to 16 weeks to monitor treatment-related adverse events and changes in glutathione levels. During the study, participants will undergo blood specimen collection and neuroimaging to measure glutathione levels and oxidative stress markers. Researchers will evaluate these markers from baseline through 8 weeks of treatment, with additional safety monitoring up to 16 weeks. Participants will be required to attend follow-up visits and provide written consent, with the total study duration covering the treatment and observation periods.

GWICTIC: NAC Mechanistic Study in Gulf War Veterans