Actively Recruiting
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
Led by Nova Southeastern University · Updated on 2025-07-08
170
Participants Needed
7
Research Sites
121 weeks
Total Duration
On this page
Sponsors
N
Nova Southeastern University
Lead Sponsor
R
RTI International
Collaborating Sponsor
AI-Summary
What this Trial Is About
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
CONDITIONS
Official Title
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 47 and 70 years
- Served in the Gulf War Theater any time between August 1990 and July 1991
- Meets the modified Kansas case definition for Gulf War Illness, allowing stable treated conditions like hypertension, diabetes, PTSD, major depressive disorder, or mild traumatic brain injury
- Able to provide written informed consent
- Willing to attend follow-up visits
You will not qualify if you...
- Current or past major depression with psychotic or melancholic features, schizophrenia, bipolar disorder, delusional disorders, dementia, epilepsy, stroke, brain tumor, multiple sclerosis, Parkinson's disease, Alzheimer's disease, alcoholism, or drug abuse
- Severe claustrophobia or difficulty undergoing MRI (for MRS substudy)
- Presence of ferrous implanted medical devices or metal fragments under the skin (for MRS substudy)
- Heavy alcohol use exceeding 15 drinks per week or tobacco use exceeding 20 cigarettes per day
- Chronic active infections such as HIV, Hepatitis B, or Hepatitis C
- Renal disease with serum creatinine over 2.0 mg/dL
- Liver disease with bilirubin over 2.5 mg/dL or high liver enzymes
- Uncontrolled diabetes with HgbA1c above 7.5 without adequate medical care
- Diagnosed vascular disease including congestive heart failure
- Diagnosed bleeding disorders or use of blood-thinning medications
- Use of stavudine or didanosine for more than 7 days within 30 days before screening
- Diagnoses that explain fatigue symptoms
- Scheduled surgery during study or surgery within 6 weeks before screening
- Pregnancy
- Currently on dialysis
- Recent or current use of antiviral medications for more than 7 days within 30 days before screening
- Participation in another investigational clinical trial within 6 weeks before consent or planning to participate during this study
- Use of herbal medicine within 30 days before consent and screening blood draw
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
VA Palo Alto Health Care System War Related Illness and Injury Study Center
Palo Alto, California, United States, 94304
Actively Recruiting
2
Nova Southeastern University
Fort Lauderdale, Florida, United States, 33314
Actively Recruiting
3
Boston University Medical School
Boston, Massachusetts, United States, 02215
Active, Not Recruiting
4
VA New Jersey Health Care System War Related Illness and Injury Study Center
East Orange, New Jersey, United States, 07018
Actively Recruiting
5
Weill Cornell Medical College
New York, New York, United States, 10021
Active, Not Recruiting
6
RTI International
Durham, North Carolina, United States, 27709
Active, Not Recruiting
7
Michael E. DeBakey VA Medical Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
N
Nancy Klimas, MD
CONTACT
K
Karen Kesler, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here