Prospective Study of Gynecologic Patients with Vulvar or Perianal Extramammary Pagets Disease to Understand Treatment and Skin Microorganisms

What this Trial Is About

This research aims to better understand Extramammary Pagets Disease EMPD, focusing on women with vulvar or perianal Pagets disease. The study will collect tissue samples and swabs to explore the microorganisms microbiome living on or near affected skin areas. Researchers want to learn more about treatment outcomes and disease characteristics in this specific group. Participants will be identified during visits to the Dermatology or Gynecologic Surgery departments at Mayo Clinic. They will undergo cultures of skin, rectum, and vagina to analyze the microbiome. Women will follow a care pathway including dermatology consultations, preoperative genital sensory testing, and possibly Mohs micrographic surgery or excisional procedures by gynecologic surgery. Samples such as swabs, urine, and tissue will be collected before interventions for further analysis. During the study, participants will complete various sexual health and quality of life questionnaires. They will be monitored for outcomes including long-term survival over 25 years. The study collects data through physical exams, questionnaires, tissue sampling, and clinical follow-up. This observational registry aims to gather comprehensive information on EMPD in women, supporting better understanding and care.

Gynecologic Extramammary Paget's Disease