Actively Recruiting
HA35 Acute Alcohol Study
Led by The Cleveland Clinic · Updated on 2025-11-17
24
Participants Needed
1
Research Sites
295 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day. This study visit will include a medical exam, clinical labs, questionnaires, body composition measurements, and urine and stool collections. Additionally, participants will consume a sugar cocktail to measure their gut permeability, participate in an acute ethanol challenge, and undergo two muscle biopsies. The study will take approximately 3-4 hours and a designated driver will need to drive the participant home. On the fifth day, you will be asked to return to drop of the 24-hour urine collection.
CONDITIONS
Official Title
HA35 Acute Alcohol Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Alcohol consumption of less than 7 drinks per week for women and less than 14 drinks per week for men
- Ability to understand and willingness to provide written consent
You will not qualify if you...
- Any known chronic illness including but not limited to cancer (except non-melanoma skin cancer)
- Poorly controlled diabetes (Hemoglobin A1c >9.5 g/dl)
- Untreated hyper/hypothyroidism
- Uncontrolled hypertension or hypercholesterolemia
- End-stage renal disease
- Liver disease of any etiology
- Coronary artery disease or stroke
- Active intravenous drug use
- History of gastric bypass
- Medications known to alter muscle protein synthesis (systemic corticosteroids, tamoxifen, high dose estrogen, testosterone, or anabolic steroids)
- Pregnancy
- Past alcohol use disorder
- Abnormal clotting factors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
S
Srinivasan Dasarathy, MD
CONTACT
A
Annette Bellar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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