Actively Recruiting
Handgrip Exercise Training and CKD
Led by Emory University · Updated on 2026-02-12
50
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to find out if regular handgrip exercise performed at home can improve blood pressure at rest and during exercise in patients with chronic kidney disease (CKD). This study is also intended to understand what causes an increase in blood pressure at rest and during exercise (i.e., increased adrenaline levels, or decreased ability of blood vessels to dilate). Patients with CKD will be recruited from primary care, Nephrology and other subspecialty Clinics throughout the Emory Healthcare System. Participants will attend 4 visits of 2-3 hours and 3 visits of 1-2 hours. The home exercise training will last for 8 weeks.
CONDITIONS
Official Title
Handgrip Exercise Training and CKD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with chronic kidney disease (CKD) stages IIIa and IV
- Age between 45 and 85 years
- Exercise less than 20 minutes twice per week
- Stable kidney function with estimated glomerular filtration rate (eGFR) between 15 and 59 cc/minute
- No more than 20% reduction in eGFR over the prior 3 months
- Willing and able to follow the study protocol
You will not qualify if you...
- Severe CKD with eGFR less than 15 cc/minute
- Metabolic alkalosis with serum bicarbonate over 28 meq/L
- Ongoing drug or alcohol abuse
- Diabetic neuropathy
- Any serious disease that may affect survival
- Severe anemia with hemoglobin less than 10 g/dL
- Heart failure or ejection fraction below 35%, symptomatic heart disease, or treatment with central alpha agonists
- Uncontrolled high blood pressure above 170/100 mm Hg
- Low blood pressure below 100/50 mm Hg
- Pregnancy or plans to become pregnant
- Current treatment with MAO inhibitors
- Inability to perform handgrip exercise
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
Research Team
J
Jeanie Park, MD
CONTACT
F
Fatima Kamal
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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