Study of Blood Biomarkers and Clinical Data in Patients Undergoing Angiogram After a Heart Attack or Chest Pain

What this Trial Is About

Researchers are studying acute coronary syndromes ACS, which include heart attacks and unstable angina, to better understand the causes and improve treatments. This observational study focuses on patients who have experienced these conditions and are undergoing routine angiogram procedures. The goal is to identify new blood markers and clinical signs linked to ACS, especially those related to inflammation and micro-organism activity, to help tailor future treatments more precisely. Participants will provide blood samples during their angiogram procedure, donating about 60 milliliters for research analysis. The study includes patients with different presentations of ACS, such as those with chest pain who receive a cardiac stent and those whose angiograms show normal coronary arteries. The researchers will also gather clinical data from routine procedures like ECG, echocardiograms, and MRI scans. During the study, participants will be followed up at six weeks and six months with questionnaires during their routine clinic visits. One year after the procedure, they will receive a phone call to update information on any events and medication changes. Additional data will be collected from hospital records without contacting participants. Remaining blood samples will be securely stored for future research. The main outcome is to find new biomarkers and clinical parameters associated with ACS over a two to five-year period.

The Harefield Acute Myocardial Infarction Cohort