Actively Recruiting
Harm Reduction in HIV Primary Care for PLWH Who Use Drugs
Led by University of Pittsburgh · Updated on 2026-04-24
768
Participants Needed
3
Research Sites
271 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
A
Allegheny Health Network
Collaborating Sponsor
AI-Summary
What this Trial Is About
People living with HIV (PLWH) who use drugs experience significant health disparities including lower rates of retention in HIV care and higher rates of unsuppressed viral load, resulting in secondary infections and increased mortality. The proposed study will used mixed methods to explore (a) the relationship between healthcare providers' attitudes towards working with PLWH who use drugs and providers' acceptance and practice of structural and relational harm reduction; (b) the degree to which relational harm reduction moderates the effect of intersectional stigma experienced in healthcare settings on patients' perceptions of their relationship with providers; (c) the degree to which structural HR moderates the relationship between the patient-provider relationship and clinical outcomes, and (d) whether patient-perceived HR approaches to care are directly associated with HIV clinical outcomes. The study will also use these findings to inform the development and pre-testing of an intervention to operationalize harm reduction in HIV clinical settings, using stakeholder-engaged and human-centered design approaches, presenting a novel path to reducing HIV health inequities for PLWH who use drugs.
CONDITIONS
Official Title
Harm Reduction in HIV Primary Care for PLWH Who Use Drugs
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Providers must have worked at one of the 3 study sites or their partner substance use treatment sites for at least one year
- Providers must provide care or services to people living with HIV or people who use drugs at high risk for HIV
- Providers must work in roles such as front desk/patient engagement, social worker, nurse, medical assistant, advanced practice provider, or physician
- Providers must be able to verbally consent, read, and speak English
- Patients must be living with HIV
- Patients must be age 18 or older
- Patients must be able to verbally consent, read, and speak English
- Patients must have received HIV medical care from one of the study sites for at least one year
- Patients must have lifetime or recent (past 3 months) use of illicit substances (excluding marijuana) or prescription drugs for non-medical reasons as defined by the NIDA-Modified ASSIST 2.0
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 3 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35222
Actively Recruiting
2
Allegheny Health Network Research Institute
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
3
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
M
Mary Hawk, DrPH
CONTACT
S
Stephanie Creasy, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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