Actively Recruiting
Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair
Led by University of Missouri-Columbia · Updated on 2024-06-12
180
Participants Needed
3
Research Sites
354 weeks
Total Duration
On this page
Sponsors
U
University of Missouri-Columbia
Lead Sponsor
W
Washington University School of Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study adopts a strategy that has arisen from basic neuroscience research on facilitating adaptive brain plasticity and applies this to rehabilitation to improve functional recovery in peripheral nervous system injuries (including hand transplantation, hand replantation, and surgically repaired upper extremity nerve injuries). The technique involves combining behavioral training with transcranial direct current stimulation (tDCS)-a non-invasive form of brain stimulation capable of facilitating adaptive changes in brain organization.
CONDITIONS
Official Title
Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Received a unilateral allogeneic hand transplant above the wrist and are 12 to 18 months post-surgery with Tinel's sign at distal fingertips
- Had a complete hand amputation between the wrist and elbow followed by successful re-attachment and are 12 to 18 months post-surgery with Tinel's sign at distal fingertips
- Underwent nerve repairs (median, ulnar, or related nerves) after complex forearm injuries between wrist crease and flexor musculotendinous junctions and are 12 to 18 months post-surgery with Tinel's sign at distal fingertips
You will not qualify if you...
- Significant or severe brain trauma
- Serious psychiatric conditions
- Chronic or severe neurological conditions
- Current pregnancy
- History of seizures or unexplained loss of consciousness
- Metallic implants above the chest
- Certain implanted medical devices
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Christine Kleinert Institute for Hand & Microsurgery
Louisville, Kentucky, United States, 40202
Actively Recruiting
2
University of Missouri
Columbia, Missouri, United States, 65211
Actively Recruiting
3
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
S
Scott H Frey, Ph.D., Ed.M.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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