Actively Recruiting
HCAPPED I: HCAP-Pcr in Emergency Department
Led by Azienda Ospedaliero-Universitaria Careggi · Updated on 2024-07-17
93
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Prospective Observational Study (on Diagnostic Procedure) - Single-Center, Non-Profit. A pilot study will be conducted on a prospective cohort of patients with HCAP (Healthcare-Associated Pneumonia). This study will be conducted on a single arm of patients. No control group or randomization is planned. The use of syndromic molecular panels in pneumonias with risk factors for MDR (multidrug-resistant) pathogens, such as in patients with HCAP, has become common practice. However, the use of this tool is reserved for patients with severe forms of HCAP (PIRO\>2, at least moderate ARDS, and respiratory failure requiring high-flow oxygen during sepsis) (30), and it is not yet standardized by international guidelines. The decision to use this tool or not is currently at the clinician\'s discretion and is usually reserved for the severe forms mentioned above. The study aims to determine if the early use of this tool has a real benefit on the management of antibiotic therapy for these patients in terms of therapeutic changes compared to corporate and international guidelines. Duration of patient enrollment: 1 year. Duration of the study: 1.5 years.
CONDITIONS
Official Title
HCAPPED I: HCAP-Pcr in Emergency Department
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old undergoing bronchoalveolar lavage in the Emergency Department
- Admitted with clinically and radiologically confirmed healthcare-associated pneumonia (HCAP)
- Rankin score less than 5
- Meet at least one: need for high-flow oxygen therapy, intubation, SOFA score 2 or higher, PSI score over 85 (age 75+ with renal insufficiency), or Horowitz index (PaO2/FiO2) below 200
You will not qualify if you...
- Lack of consent
- Age under 18 or over 90
- Pregnancy
- Life expectancy less than 3 months
- Hospital admission over 48 hours (hospital-acquired pneumonia)
- Rankin score 5 or higher
- Community-acquired pneumonia (CAP)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Azienda ospedaliero universitaria careggi
Florence, Tuscany/Italy, Italy, 50122
Actively Recruiting
Research Team
P
Pelagatti Lorenzo, Dr
CONTACT
P
Pelagatti Lorenzo, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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