Study of Heart Muscle Changes and Risks in Adults with Hypertrophic Cardiomyopathy Using Follow-Up Imaging

What this Trial Is About

Researchers are investigating factors that may predict heart problems, such as sudden death from fast heart rhythms or heart failure, in people with hypertrophic cardiomyopathy HCM. This genetic condition causes the heart muscle to thicken, which can make the heart stiff and affect its electrical system. The study aims to follow up on patients previously involved in a research project called HCMR - Novel Predictors of Outcome in Hypertrophic Cardiomyopathy to better understand the role of late gadolinium enhancement LGE, a substance collected in heart muscle that may indicate higher risk for heart complications. This observational study will involve patients from the original HCMR cohort, divided into groups with obstructive and non-obstructive HCM based on specific heart measurements. The study will use follow-up imaging to assess changes in LGE over a minimum of seven years. No new treatments are given instead, the study observes how the condition progresses and how LGE is related to heart problems. Participants will undergo regular imaging assessments to track changes in the percentage of LGE mass in their heart muscle compared to baseline measurements. The research team will monitor heart function and symptoms over time. The study will last several years, providing valuable information about the progression of HCM and the risks associated with LGE in affected individuals.

HCMR Re-Imaging Study