Actively Recruiting
HCMR Re-Imaging Study to Follow Up on Heart Imaging in Hypertrophic Cardiomyopathy
Led by Christopher Kramer · Updated on 2026-03-18
314
Participants Needed
8
Research Sites
17 weeks
Total Duration
On this page
Sponsors
C
Christopher Kramer
Lead Sponsor
B
Brigham and Women's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating factors that may predict heart problems, such as sudden death from fast heart rhythms or heart failure, in people with hypertrophic cardiomyopathy (HCM). This genetic condition causes the heart muscle to thicken, which can make the heart stiff and affect its electrical system. The study aims to follow up on patients previously involved in a research project called "HCMR - Novel Predictors of Outcome in Hypertrophic Cardiomyopathy" to better understand the role of late gadolinium enhancement (LGE), a substance collected in heart muscle that may indicate higher risk for heart complications. This observational study will involve patients from the original HCMR cohort, divided into groups with obstructive and non-obstructive HCM based on specific heart measurements. The study will use follow-up imaging to assess changes in LGE over a minimum of seven years. No new treatments are given; instead, the study observes how the condition progresses and how LGE is related to heart problems. Participants will undergo regular imaging assessments to track changes in the percentage of LGE mass in their heart muscle compared to baseline measurements. The research team will monitor heart function and symptoms over time. The study will last several years, providing valuable information about the progression of HCM and the risks associated with LGE in affected individuals.
CONDITIONS
Brief Title
HCMR Re-Imaging Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients from the original HCMR study with obstructive or non-obstructive hypertrophic cardiomyopathy
- Adults aged 18 to 65 years
- Body mass index (BMI) less than 35 kg/m2 for obstructive HCM; less than 40 kg/m2 for non-obstructive HCM
- Specific heart pressure measurements as defined for obstructive and non-obstructive groups
- For obstructive HCM: New York Heart Association (NYHA) Class II or III symptoms
- For non-obstructive HCM: elevated NT-proBNP levels over 300 pg/mL and left ventricular ejection fraction (LVEF) of 55% or higher
You will not qualify if you...
- History of paroxysmal atrial fibrillation or flutter before joining
- Atrial fibrillation requiring rhythm treatment within 6 months prior to joining, unless well-controlled with anticoagulation for over 6 months
- History of fainting or sustained ventricular arrhythmia with exercise within 6 months before joining
- Pregnancy due to potential risk from gadolinium contrast
- Dependence on a pacemaker, as MRI cannot be performed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Minimum of 7 years
Participants undergo periodic heart imaging assessments and clinical evaluations to monitor changes in hypertrophic cardiomyopathy over several years.
Follow-up imaging and assessments at intervals over 7 years
Trial Site Locations
Total: 8 locations
1
Northwestern
Evanston, Illinois, United States, 60208
Not Yet Recruiting
2
Brigham & Women's Hospital
Boston, Massachusetts, United States, 02115
Not Yet Recruiting
3
Tufts Medical Center
Medford, Massachusetts, United States, 02155
Not Yet Recruiting
4
University of Michigan
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
5
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Not Yet Recruiting
6
University of Virginia
Charlottesville, Virginia, United States, 22903
Actively Recruiting
7
University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom, B15 2GW
Not Yet Recruiting
8
London Chest Hospital
London, United Kingdom, E2 9JX
Not Yet Recruiting
Research Team
G
Gina Duda
T
Thuy Le
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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