Head Positioning Duration After Retinal Detachment Repair With Vitrectomy and Gas

What this Trial Is About

Researchers are evaluating if one day of post-operative prone head positioning is as effective as seven days in patients with retinal detachments involving inferior retinal breaks after pars plana vitrectomy PPV using perfluoropropane C3F8 gas as a tamponade. This single-arm phase II study uses a Simons two-stage design to assess anatomical retina success rates and determine if shorter head positioning is promising for further research. Participants will receive retina re-attachment repair with C3F8 gas tamponade followed by one day of post-operative prone head positioning. The study will enroll 20 patients in two stages 11 patients in the first stage with early stopping rules based on success rates, and if criteria are met, 9 more patients in the second stage. The goal is to achieve retina attachment success in at least 85 of patients. During the study, participants will be monitored for retina attachment using clinical exams with an indirect ophthalmoscope at 3 months and 1 year post-surgery. Researchers will track anatomical success and safety outcomes throughout the follow-up period. The total participation duration varies based on the two-stage design and follow-up assessments. The University of Kansas Medical Center sponsors this trial.

Head Positioning After Retina Detachment Repair