Observational Study of Headache Patients Aged 6 to 70 Years Establishing a Precision Diagnosis and Treatment System Led by Tongji Hospital, HUST

What this Trial Is About

Headache is a common and complex condition affecting many people globally, often leading to a reduced quality of life. This study aims to build a clinical cohort and develop a precise diagnosis and treatment system for headaches using advanced biotechnologies, multi-omics detection, and big data analysis. The research is part of a major project in Hubei Province focusing on genetic big data and seeks to improve headache diagnosis and treatment approaches. The study is a multi-center, prospective observational research involving 50,000 headache patients from various centers in China. It collects detailed clinical, epidemiological, imaging, and questionnaire data, along with biological samples from 1,500 patients at Tongji Hospital. Participants will be followed up monthly for the first three months with face-to-face interviews, then annually via telephone for up to 10 years. The study integrates clinical data with biological and multi-omics information to support precision medicine development. Participants will provide detailed headache histories and undergo various assessments including blood sample collection, imaging, and questionnaires. The research tracks medication use, treatment effects, and adverse reactions over time. The main outcome is the development of an integrated precision diagnosis and treatment system for headaches, with secondary outcomes including brain network and biomarker studies, treatment efficacy, and identification of new therapeutic targets. This long-term study offers extensive data collection and follow-up to support improved headache care.

Headache Registration and Followup Initiated by Tongji Hospital, HUST