Actively Recruiting
The Healthy Elderly Longevity Cohort Observational Study on Genetics and Health in Adults 80 Years and Older
Led by Scripps Translational Science Institute · Updated on 2025-01-17
5000
Participants Needed
1
Research Sites
1169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are exploring how genetic differences influence health and disease, especially in older adults. This study focuses on individuals aged 80 years or older, aiming to understand how the genome interacts with environmental factors to maintain health and how aging affects this balance. The study seeks to model health and disease phenotypes through population genomics, using the latest genome-sequencing technologies. The growing older population in the US highlights the importance of studying health mechanisms in this age group to potentially reduce medical costs and improve well-being. Participants will provide blood and/or saliva samples, which may be used for whole genome sequencing if feasible. The study involves collecting these samples to create a resource for analyzing genetic and health data. There are no specific interventions or treatments applied; the focus is on sample collection and data modeling. The study does not mention separate treatment or extension phases. During the study, participants will be asked to provide biological samples and comply with protocol procedures. Researchers will monitor health and genetic data over time, focusing on building a biorepository with long-term storage planned for ten years. The study emphasizes the importance of cooperation and informed consent. Participants' health status, including mild age-related conditions, will be considered in the analysis to better understand aging and health.
CONDITIONS
Official Title
The Healthy Elderly Longevity Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 80 years or older
- Eligible for blood draw and/or saliva collection
- Be reliable, cooperative and willing to comply with all protocol-specified procedures
- Able to understand and grant informed consent
- Be healthy or have mild medical conditions associated with normal aging, including well-controlled hypertension (no more than 3 medications), osteoporosis, osteopenia, osteoarthritis, benign prostatic hypertrophy, cataracts, glaucoma, macular degeneration, dyslipidemia, hypothyroidism, or pre-diabetes/impaired fasting glucose (fasting blood glucose 100-126 mg/dL, if known)
You will not qualify if you...
- Younger than 80 years old
- Previously enrolled in The Scripps Genebank Healthy Elderly Cohort
- Treatment with any investigational agents or devices within 30 days before enrollment
- History or current diagnosis of significant chronic conditions, including any cancer (except basal or squamous cell skin cancer), coronary artery disease/myocardial infarction, stroke/transient ischemic attack, deep vein thrombosis/pulmonary embolus, chronic renal disease/hemodialysis, significant autoimmune/inflammatory conditions (e.g., rheumatoid arthritis, lupus, Crohn's), Alzheimer's or Parkinson's disease, diabetes with hemoglobin A1C > 6.5% or fasting glucose >126 mg/dL or treated with diabetic medications/insulin if known, aortic or cerebral aneurysm
- Regular use of medications such as oral chemotherapeutic agents (e.g., tamoxifen, doxorubicin), anti-platelet agents excluding aspirin (e.g., clopidogrel), cholinesterase inhibitors for Alzheimer's (e.g., donepezil), or insulin
- Significant medical conditions that may interfere with study participation or confound results, as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Scripps Translational Science Institute
La Jolla, California, United States, 92037
Actively Recruiting
Research Team
S
Sarah Topol, BS
E
Emily Spencer, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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