Actively Recruiting
Healthy Little Eyes
Led by University of Wisconsin, Madison · Updated on 2026-05-14
125
Participants Needed
1
Research Sites
487 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
M
Meriter Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to gather more information on how eye injury is related to a baby's future development and see if eye function and brain test results can be used, along with current measures, to better diagnose and treat babies with hypoxic-ischemic encephalopathy (HIE). Participants will undergo up to two eye exam sessions, involving both Visual Evoked Potential (VEP) and Electroretinogram (ERG) exams.
CONDITIONS
Official Title
Healthy Little Eyes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Inpatient neonates diagnosed with hypoxic-ischemic encephalopathy (HIE)
- Pediatric patients less than 78 hours old at enrollment
- Parent or legal guardian able to complete consent in English
- Pediatric patients diagnosed with HIE presenting to follow-up clinics
- Pediatric patients younger than 36 months at enrollment
- Healthy newborns in Meriter's Newborn Nursery
- Gestational age between 37 and less than 42 weeks
- 5-minute Apgar score of 7 or higher
- Occipital Frontal Circumference within average limits (3rd to less than 97th percentile)
You will not qualify if you...
- Prenatally diagnosed or congenital brain or eye abnormalities not related to HIE
- Known central nervous system illnesses other than HIE
- Parent or legal guardian unable to provide informed consent (including foster care, state custody, or minor parents)
- Admission to NICU for any reason (healthy babies)
- Known genetic abnormalities
- Diagnosed with hypoglycemia or hyperbilirubinemia requiring phototherapy
- Prenatal exposure to substances like illicit drugs, alcohol, or tobacco
- Neonatal infections requiring treatment
- TORCH infections
- Abnormal newborn hearing or toxicology screening
- Large or small for gestational age
- Eye abnormalities such as microphthalmia, anophthalmia, congenital cataract, congenital glaucoma, optic nerve hypoplasia, nystagmus, and others
- Central nervous system malformations or illnesses such as brain malformations or hydrocephalus
- Lack of approval from the attending medical team
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
A
Alexandra Lindstrom
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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