Impact of Different Priming Solutions on Acid-Base Balance, Electrolytes, and Outcomes in Adults Undergoing Heart-Lung Machine Cardiac Surgery

What this Trial Is About

This research investigates how different priming solutions used in the heart-lung machine affect the bodys acid-base balance, electrolyte levels, and clinical outcomes during cardiac surgery. The study focuses on patients undergoing coronary artery bypass graft or aortic valve replacement surgery, aiming to fill knowledge gaps about optimal priming fluid composition for better patient care and safety. Participants are randomly assigned to one of four groups receiving different priming solutions Ringers Acetate alone, Ringers Acetate with 80 mmol sodium chloride, Ringers Acetate with 160 mmol sodium chloride, or Plasmalyte alone. Each solution is used to fill the heart-lung machine circuit with 1100 mL before connecting to the patient. This approach helps compare how these fluids influence the bodys chemical balance during surgery. Throughout the study, blood samples are collected at various times before, during, and after surgery to measure acid-base balance, sodium levels, osmolality, and other electrolytes. Urine output and hydration status are monitored until the first postoperative day. Additional kidney function and neurological assessments are performed up to three months after surgery. This comprehensive monitoring helps researchers evaluate the impact of each priming solution on patient health and recovery.

Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery