Actively Recruiting
Evaluation of Autonomic Function Using Short-Term Heart Rate Variability in Patients With Benign Paroxysmal Positional Vertigo: A Prospective Case-Control Study
Led by Istanbul Aydın University · Updated on 2026-04-16
104
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Benign paroxysmal positional vertigo (BPPV) is a common peripheral vestibular disorder often linked to the displacement of tiny crystals in the inner ear. Recent research suggests a relationship between psychological stress, anxiety, and BPPV onset or recurrence, but the underlying biological mechanisms are not well understood. This study aims to assess autonomic nervous system function in BPPV patients by measuring heart rate variability (HRV) and comparing results with healthy individuals. Participants will undergo short-term HRV assessments using a non-invasive device that records heart rhythm variability through hand electrodes. Measurements will be taken while resting and during controlled breathing to evaluate vagal tone and autonomic balance. The study includes two groups: patients diagnosed with BPPV confirmed through positional testing and healthy volunteers matched by age, sex, and body mass index. Stress levels will also be evaluated using the Perceived Stress Scale (PSS-10). Participants will attend a single visit for HRV measurement and stress assessment. Researchers will analyze primary outcomes including RMSSD and coefficient of variation of RR intervals from HRV recordings, comparing these between BPPV patients and controls. Secondary outcomes explore changes in these measures during controlled breathing. This approach aims to provide insight into autonomic regulation and stress-related influences in BPPV. The entire participation consists of one visit with no additional follow-up required.
CONDITIONS
Brief Title
Heart Rate Variability in Benign Paroxysmal Positional Vertigo
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Clinical diagnosis of benign paroxysmal positional vertigo (BPPV) confirmed by positional testing with positional nystagmus
- No known history of cardiac disease
- Ability and willingness to provide written informed consent
- For healthy controls: no history of vertigo or vestibular disorder
- Healthy controls matched by age and sex to BPPV patients
You will not qualify if you...
- Age younger than 18 years
- Inability to provide informed consent or impaired mental capacity
- Known arrhythmia, heart failure, ischemic heart disease, or other significant cardiac disorder
- Use of medications affecting heart rate variability such as beta-blockers, certain calcium channel blockers, antiarrhythmic drugs, digoxin, corticosteroids, sympatholytic agents, or psychotropic medications
- Active infection or systemic inflammatory disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single visit
Participants undergo short-term heart rate variability (HRV) measurement using a non-invasive device to assess autonomic function at rest and during controlled breathing.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Medicalpark Florya Hospital
Istanbul, Küçükçekmece, Turkey (Türkiye), 34295
Actively Recruiting
Research Team
D
Dastan Temirbekov, assistan professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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