Actively Recruiting
HEARTS Trial for Thoracic Cancers
Led by University of Wisconsin, Madison · Updated on 2026-03-11
60
Participants Needed
1
Research Sites
177 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare a new way of using magnetic resonance-guided adaptive radiation therapy (MRgART) to the standard of care linear accelerator (LINAC) radiation treatment in people with cancer in the thoracic region near the heart. The main question it aims to answer is whether MRgART affects the heart differently than LINAC. Participants will: * Receive radiation therapy * Undergo MRIs and bloodwork * Complete quality of life questionnaires
CONDITIONS
Official Title
HEARTS Trial for Thoracic Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years at the time of consent
- Dosimetric eligibility met using QUANTEC endpoints (>10% of heart receives > 25 Gy) through rapid auto-planning
- Histologically or cytologically proven cancer including Stage IIB-IV non-operable non-small cell lung cancer
- Limited stage small cell lung cancer with once daily treatment
- Stage I-III N0-2 esophageal or esophagogastric cancer
- Stage II or III thymoma or thymic carcinoma
- Other thoracic region cancers meeting dosimetric and trial criteria
- Planned daily fractionated radiation therapy with at least 15 treatment fractions, typically 1.8 to 4 Gy per fraction
You will not qualify if you...
- Evidence of metastatic disease with life expectancy less than 12 months
- Prior thoracic radiotherapy significantly overlapping the heart region
- Contraindications to MRI
- Severe active co-morbidity with New York Heart Association Functional Classification III or IV
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin - Madison
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
C
Cancer Connect
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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