Actively Recruiting
Height Adjusted Versus Standardized Dose of Bupivacaine for Spinal Anesthesia
Led by University Hospital, Caen · Updated on 2025-07-25
250
Participants Needed
1
Research Sites
253 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
General anesthesia during pregnancy is associated with several major risks including unanticipated difficult airway, pulmonary aspiration, and specific anesthetic effects on the newborn. Thus, intrathecal anesthesia is the technique of choice for cesarean section. Nevertheless, the main side effect of intrathecal anesthesia is arterial hypotension which depend mainly on the dose of local anesthetic administered intrathecally. To date there is no guidelines nor evidences whic help the anesthetist to precisely estimate the required dose. Most often a "standardized dose" of 8 to 10 mg of bupivacaine is administered. However, some data suggest that a lower dose may be administered resulting in less frequent arterial hypotension. Nevertheless, a well designed randomized study is lacking.
CONDITIONS
Official Title
Height Adjusted Versus Standardized Dose of Bupivacaine for Spinal Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled cesarean section with intrathecal anesthesia
- Term pregnancy more than 35 weeks
- Signed informed consent
You will not qualify if you...
- Unscheduled or emergency cesarean section
- Any contraindication to intrathecal anesthesia
- Use of antihypertensive drugs during pregnancy
- Presence of pre-eclampsia or eclampsia
- History of Marfan or Ehlers Danlos disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Caen University Hospital
Caen, France
Actively Recruiting
Research Team
J
jean-luc hanouz, M.D, Ph.D
CONTACT
T
thérèse simonet, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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