The effects on sensorial block, motor block, and haemodynamics of levobupivacaine at different temperatures applied in the subarachnoid space.
Bahittin Nazli, Huseyin Oguzalp, Eyup Horasanli...
https://pubmed.ncbi.nlm.nih.gov/24772412Actively Recruiting
Led by Shaheed Mohtarma Benazir Bhutto Institue of Trauma · Updated on 2026-01-23
104
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating whether using a height-based dosing method for spinal anesthesia provides better heart and blood pressure stability along with improved anesthetic effects compared to a fixed dose in elderly patients undergoing lower limb orthopedic surgeries. The study aims to determine if height-based dosing reduces risks of low blood pressure and slow heart rate during surgery and whether it improves the onset and duration of sensory and motor block. This investigation focuses on patients aged 60 to 80 scheduled for elective lower limb surgeries under spinal anesthesia. Participants will be randomly assigned to one of two groups. Group A will receive a dose of 0.07 mg per cm of 0.5% Hyperbaric Bupivacaine combined with 2 mg of preservative-free Dexamethasone injected into the spinal space. Group B will receive a conventional fixed dose of 12.5 mg of 0.5% Hyperbaric Bupivacaine with the same amount of Dexamethasone. Spinal anesthesia will be administered in the sitting position at the L3-4 vertebra, followed by monitoring sensory and motor block using standard techniques. Patients will be positioned supine after injection for assessment. During the procedure, heart rate and blood pressure will be continuously monitored to detect bradycardia and hypotension. Sensory and motor block onset and duration will be recorded until their resolution. Data including demographics and clinical characteristics will be collected and securely stored for analysis. The study includes preloading with IV fluids before anesthesia and follows patients in the early postoperative period to monitor anesthetic effects. Participation lasts through surgery and immediate recovery, with all safety data documented carefully.
CONDITIONS
HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for consent and eligibility assessment
Duration - Day of surgery
Participants receive spinal anesthesia with either height-based or conventional dosing during lower limb orthopedic surgery. Hemodynamic and anesthetic outcomes are monitored continuously during this period.
1 surgical procedure visit (in-person) with continuous monitoring
Duration - Until the end of sensory and motor blockade
Participants are observed in the early postoperative period to monitor the duration of sensory and motor blockade and any hemodynamic changes.
Approximately 1 to 2 visits post-surgery
Total: 1 location
1
Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Karachi, Sindh, Pakistan, 74600
Actively Recruiting
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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