Actively Recruiting
Hemadsorption to Enhance Drug Elimination in Intoxications
Led by Universitair Ziekenhuis Brussel · Updated on 2025-05-15
18
Participants Needed
1
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with prolonged impaired consciousness. This is a one arm interventional investigation where a hemadsorption filter is applied in patients fulfilling inclusion criteria 8 hours after admission. Plasma titer of the neurodepressing drug will be collected sequentially both before and after start of hemadsorption to evaluate the speed of drug elimination before and after application of a hemadsorption filter. Pre- and post filter titers will be obtained to evaluate adsorbability and to evaluate time to saturation of the filter.
CONDITIONS
Official Title
Hemadsorption to Enhance Drug Elimination in Intoxications
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Older than 18 years
- Admission to ICU
- Glasgow Coma Scale less than 8 or requiring Flumazenil 8 hours after hospital admission
- Intoxication with a measurable benzodiazepine or tricyclic antidepressant
- At least one risk factor for delayed drug elimination such as Cirrhosis CHILD B/C or chronic kidney insufficiency KDIGO 3b or worse
You will not qualify if you...
- Pregnant patient
- Patients on chronic dialysis before admission
- Need for mechanical ventilation for reasons other than intoxication (e.g., pneumonia, neurotrauma)
- Condition requiring continued intravenous sedation
- Known history of seizures
- Contraindication to heparin use
- Do Not Resuscitate order restricting mechanical ventilation or dialysis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Universitair Ziekenhuis Brussel
Brussels, Brussels Capital, Belgium, 1090
Actively Recruiting
Research Team
M
Marie-Claire vanmalderen, Study coordinator
CONTACT
M
Merel Stevens, Study coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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