Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury: Chronic Stress and Anemia Recovery Following Major Trauma

What this Trial Is About

Traumatic injury is a major cause of illness and death in young adults, leading to significant health and economic challenges. This research aims to understand how severe trauma affects hematopoietic stem cells (HSCs) in bone marrow and muscle cells, especially in elderly patients compared to non-injured individuals. The study focuses on the body's emergency response involving myeloid cells and how this response impacts immune function and muscle loss after trauma. Participants are divided into three groups: those undergoing elective hip surgery, trauma patients, and healthy bone marrow donors from a tissue bank. Bone marrow and blood samples will be collected during surgery or from the tissue bank. These samples will be analyzed for various factors such as genomic expression, oxidative stress, mitochondrial activity, and immune cell function using laboratory tests including ELISAs and assays for erythropoietin and iron levels. During hospitalization, clinical and hemodynamic data will be collected daily for trauma patients, who will also be monitored for bone healing and need for additional surgery. Researchers will measure genomic responses in hematopoietic cells and assess muscle dysfunction through several biological markers. The study seeks to understand injury-associated anemia and muscle loss, with follow-up care continuing until the study ends.

Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury