Radiation Therapy After Pleural Decortication for Treating Malignant Pleural Mesothelioma Phase II Lung-Sparing Multimodality Treatment Study

What this Trial Is About

Malignant Pleural Mesothelioma is a severe and difficult-to-treat cancer. Researchers are studying the safety and effects of a special radiation treatment called hemithoracic Volumetric Arc Radiotherapy after surgery called Pleural decortication. This study is part of a combined treatment approach that starts with chemotherapy, followed by surgery, then radiation, aiming to reduce cancer recurrence while minimizing side effects. Participants will first receive chemotherapy and then surgery to remove the affected pleura. After surgery, all patients will undergo a targeted radiation therapy to the side of the chest that had surgery. This radiation is delivered postoperatively to focus on the area at risk, with the goal of eliminating remaining cancer cells. During the radiation treatment, participants will be monitored weekly for any acute side effects. After the radiation course, follow-up visits will occur monthly for six months to check for late side effects, and then every two months for at least another six months. The researchers will carefully assess both immediate and delayed toxicities to evaluate the safety and overall impact of this radiation therapy. The total participation duration includes the treatment and follow-up periods as described.

Hemithoracic Arc Radiotherapy Post Pleural Decortication