Actively Recruiting
Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma
Led by University College, London · Updated on 2026-03-30
148
Participants Needed
25
Research Sites
287 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
A
Asthma + Lung UK
Collaborating Sponsor
AI-Summary
What this Trial Is About
Phase III randomised-controlled trial for patients with unilateral malignant pleural mesothelioma (MPM).
CONDITIONS
Official Title
Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older with biopsy-confirmed malignant pleural mesothelioma and histological subtyping (epithelioid or non-epithelioid)
- N0 or N1 and M0 disease stage
- Written informed consent provided
- Patient and local/regional multidisciplinary team choose active surveillance and delay systemic anti-cancer therapy until progression
- WHO Performance Status of 0 or 1
- Disease confined to one hemithorax based on CT scan
- Adequate lung function with predicted post-bronchodilator FEV1 of at least 40% and DLCO/TLCO of at least 40%
- Agreement to travel to proton beam therapy centers (UCLH or The Christie) if randomized to experimental arm
- Agreement to follow-up at a local HIT-Meso trial site
- Patient likely able to complete proton beam therapy planning based on assessment
You will not qualify if you...
- Presence of metastatic or disease on opposite side of chest
- Cytological diagnosis only or unclear histological subtype
- Prior thoracic radiotherapy, chemotherapy, or immunotherapy for malignant pleural mesothelioma
- Prior radical surgery for malignant pleural mesothelioma (including extrapleural pneumonectomy or pleurectomy decortication)
- Need for initial systemic therapy or surgery when not opting for active surveillance
- Involvement of opposite side or supraclavicular lymph nodes
- T4 disease with heart invasion
- N2 and/or M1 disease
- New pleural effusion that cannot be drained
- WHO Performance Status of 2 or higher
- Pregnancy or breastfeeding
- Current or previous cancer that may affect life expectancy
- Presence of a pacemaker or implantable cardioverter-defibrillator
- Clinically significant interstitial lung disease excluding mild fibrosis or incidental findings
- Chronic non-cancer diseases with less than 20% estimated survival at 3 years
- Prior thoracic or abdominal radiotherapy for cancer without prior discussion with sponsor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
East Sussex Healthcare NHS Trust - Eastbourne Hospital
Eastbourne, East Sussex, United Kingdom
Actively Recruiting
2
East Sussex Healthcare NHS Trust - Conquest Hospital
Saint Leonards-on-Sea, East Sussex, United Kingdom
Actively Recruiting
3
Royal Berkshire Hospital
Reading, England, United Kingdom, RG15AN
Actively Recruiting
4
Southend University Hospital
Southend, Essex, United Kingdom, SS0 0RY
Actively Recruiting
5
Queen Alexandra Hospital
Portsmouth, Hampshire, United Kingdom
Actively Recruiting
6
Queen Elizabeth Hospital, King's Lynn
Kings Lynn, Norfolk, United Kingdom, PE30 4ET
Actively Recruiting
7
Furness General Hospital
Barrow in Furness, United Kingdom, LA14 4LF
Actively Recruiting
8
Betsi Cadwaladr University Health Board -Glan Clwyd Hospital
Bodelwyddan, United Kingdom, LL18 5UJ
Actively Recruiting
9
Southmead Hospital
Bristol, United Kingdom, BS105NB
Actively Recruiting
10
Addenbrooke's Hospital
Cambridge, United Kingdom, CB20QQ
Actively Recruiting
11
Velindre Cancer Centre
Cardiff, United Kingdom
Actively Recruiting
12
Broomfield Hospital
Chelmsford, United Kingdom, CM1 7ET
Actively Recruiting
13
Queens Centre, Castle Hill Hospital
Hull, United Kingdom, HU165JQ
Actively Recruiting
14
Royal Lancaster Hospital
Lancaster, United Kingdom, LA1 4RP
Actively Recruiting
15
St James University Hospital
Leeds, United Kingdom, LS97TF
Actively Recruiting
16
Leicester Royal Infirmary
Leicester, United Kingdom, LE1 5WW
Actively Recruiting
17
Clatterbridge Cancer Centre
Liverpool, United Kingdom, L78YA
Actively Recruiting
18
St Bartholomew's Hospital
London, United Kingdom, EC1A 7BE
Actively Recruiting
19
University College London Hospital
London, United Kingdom
Actively Recruiting
20
Maidstone Hospital
Maidstone, United Kingdom, ME169QQ
Actively Recruiting
21
Christie Hospital
Manchester, United Kingdom, M20 4BX
Active, Not Recruiting
22
Wythenshawe Hospital
Manchester, United Kingdom, M23 9LT
Actively Recruiting
23
Freeman Hospital
Newcastle upon Tyne, United Kingdom, NE77DN
Actively Recruiting
24
Weston Park Cancer Centre
Sheffield, United Kingdom, S102SJ
Actively Recruiting
25
Torbay Hospital
Torquay, United Kingdom, TQ2 7AA
Actively Recruiting
Research Team
K
Klara Sinalova
CONTACT
A
Aoife Walker
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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