Actively Recruiting
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Led by Johns Hopkins University · Updated on 2026-01-12
50
Participants Needed
1
Research Sites
224 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.
CONDITIONS
Official Title
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged between 18 and 90 years of age
- Diagnosed with heart failure with reduced ejection fraction (LV ejection fraction 40-50%)
- Can safely hold direct oral anticoagulant (DOAC) vitamin K antagonist (VKA) for 48 hours prior to the procedure
You will not qualify if you...
- Unable to interrupt VKA anticoagulation
- Point of care International Normalized Ratio (INR) > 1.5
- Pregnant patients
- Acute hospitalization or decompensation within 2 weeks prior to study date
- Participation in a study involving an investigational drug within 4 weeks prior to study date
- Inability to lie flat in the supine position
- Symptomatic hemodynamic instability at rest or during the procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
S
Steven Hsu, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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