Actively Recruiting
Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy
Led by Cairo University · Updated on 2026-03-20
90
Participants Needed
1
Research Sites
23 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging. Although multimodal analgesia is essential, options are often limited by factors such as hemodynamic instability, renal dysfunction, and coagulopathy. Intravenous paracetamol is commonly recommended for perioperative analgesia because of its opioid-sparing effect, but evidence suggests it may cause hypotension through peripheral vasodilation, particularly in critically ill patients. Most data on this effect come from observational studies, and evidence regarding its intraoperative hemodynamic impact remains limited.
CONDITIONS
Official Title
Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients, ASA I-III undergoing emergency laparotomy
You will not qualify if you...
- Severe cardiac morbidities including impaired contractility with ejection fraction < 40%, heart block, arrhythmias, or tight valvular lesions
- Hemodynamically unstable patients with mean arterial pressure < 65 mmHg or requiring vasopressors to maintain MAP > 65 mmHg
- Patients with high shock index (heart rate / systolic blood pressure > 1)
- Pregnant or lactating women
- Allergy to any of the study drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cairo University
Cairo, Cairo Governorate, Egypt
Actively Recruiting
Research Team
M
Maha Mostafa
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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