Actively Recruiting
Hemodynamic Instability of Patient With Spontaneous Subarachnoid Hemorrhage
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2024-04-11
90
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the role of biomarkers in spontaneous subarachnoid hemorrhage (sSAH) as predictors of severity of clinical outcome. The test of biomarkers is based on regular blood and urinary samples. Blood levels of highly specific cardiac troponin (cTNI), natriuretic peptides (NT-ProBNP), S100 beta protein, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase (UCH-L1), soluble Tumor Necrosis Factor Receptor-2 (sST2), and soluble urokinase plasminogen activator receptor (suPAR), as well as urinary levels of epinephrine and norepinephrine are the biomarkers explored. All adult participants with spontaneous subarachnoid hemorrhage are involved in the study. The main questions aim to answer are: * which of these molecules can be prognostic for patients' outcome * which are the prognostic levels of these biomarkers to predict patients' outcome. Participants will undergo blood and urinary samples during hospitalization at 24 hours, 72 hours and after 7 days.
CONDITIONS
Official Title
Hemodynamic Instability of Patient With Spontaneous Subarachnoid Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with spontaneous subarachnoid hemorrhage, including perimesencephalic and aneurysmal subarachnoid hemorrhage
- Adult patients (18 years or older)
- Confirmed spontaneous subarachnoid hemorrhage by neuroimaging
- Informed consent obtained for study biomarkers
You will not qualify if you...
- Age younger than 18 years
- Post-traumatic subarachnoid hemorrhage
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A. Gemelli IRCCS
Roma, Italy, 00168
Actively Recruiting
Research Team
G
Giuseppe Maria Della Pepa
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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