Studying How Norepinephrine Affects Blood Flow and Tissue Perfusion in Adults with Septic Shock in the ICU

What this Trial Is About

Researchers are investigating the effects of norepinephrine, a common medication used to treat septic shock, on blood flow and tissue perfusion in adults. Septic shock can cause a mismatch between overall blood circulation and the actual delivery of blood to cells, and this study aims to better understand how norepinephrine influences these factors. This observational study will provide important insights to help tailor treatment based on individual patient needs. Participants in this study are adult patients with septic shock who are sedated and mechanically ventilated in intensive care units. The study involves carefully monitored adjustments to norepinephrine dosage, including stepwise reductions and increases, alongside fluid challenges to assess how these changes affect stroke volume and blood pressure. Extended monitoring equipment will be used to collect clinical and biochemical data, and tests like the passive leg raise will help predict fluid responsiveness. During the study, researchers will continuously measure stroke volume and cardiac output using various methods, including arterial waveform analysis and Doppler ultrasound. They will evaluate how changes in norepinephrine and fluid administration impact heart function and microcirculation over approximately one year. Safety checks and detailed monitoring are integral parts of the process, ensuring participant well-being while gathering data to improve management of septic shock.

Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU