Actively Recruiting
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
Led by Copenhagen University Hospital, Hvidovre · Updated on 2025-03-07
45
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
Sponsors
C
Copenhagen University Hospital, Hvidovre
Lead Sponsor
U
University Hospital Bispebjerg and Frederiksberg
Collaborating Sponsor
AI-Summary
What this Trial Is About
In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand. Norepinephrine (NE) is recommended as first choice vasoactive agent for the treatment of septic shock. However, the dynamic effects of NE on macro- and microcirculation and perfusion parameters has not been described in detail in the context of septic shock, precluding rational individualized titration of NE and fluids, as recommended recently. In the present prospective observational multicenter study in adult septic shock patients, we intend to explore the effects of NE on preload dependency and tissue perfusion by evaluating the correlation and potential discrepancies between macro- and microcirculation both during titration of NE and after fluid resuscitation. The conclusions drawn from our study will contribute to the physiological knowledge necessary for establishing individualized evidence-based bedside management of hemodynamics in the setting of septic shock.
CONDITIONS
Official Title
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suspected or documented infection
- Need for vasopressors to maintain mean arterial blood pressure (MAP) 65 mmHg
- Serum lactate levels >2 mmol/L
- Norepinephrine infusion of > 0.2 mcg/kg/min
You will not qualify if you...
- Absolute contraindication for esophageal doppler or urinary catheter insertion as noted in the patients' charts
- Severe valvular pathology and cardiac arrhythmias causing severe hemodynamic instability
- Lithium treatment
- Treatment with other vasopressor or inotropic drugs
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hvidovre Hospital
Hvidovre, Copenhagen, Denmark, 2665
Actively Recruiting
Research Team
H
Henrik Wolsted, MD
CONTACT
N
Nicolai Bang Foss, MD, DMsC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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