Validation of Techniques for Hemodynamic Monitoring and Prediction of Fluid Responsiveness in Patients Undergoing Venovenous Extracorporeal Membrane Oxygenation - A Prospective Diagnostic Accuracy Study

What this Trial Is About

Researchers are evaluating the accuracy of various methods for monitoring blood circulation during venovenous extracorporeal membrane oxygenation (VV ECMO) treatment. This treatment supports patients with severe respiratory failure by oxygenating blood outside the body. Continuous monitoring of heart function and blood flow is crucial in intensive care, but the artificial circulation in ECMO may affect common measurement tools. The study aims to validate specific techniques for assessing fluid responsiveness and circulation in this setting. Participants will undergo serial assessments using several devices and tests, including transthoracic echocardiography, uncalibrated pulse contour analysis, transpulmonary thermodilution, bioreactance, and esophageal doppler. Fluid responsiveness will be evaluated with maneuvers like passive leg raising, pulse pressure variation, stroke volume variation, inferior vena cava ultrasound, and occlusion tests. The study compares the performance of these tools throughout ECMO therapy. During the study, patients will have repeated measurements of cardiac output and heart function over days to weeks of ECMO treatment and up to seven days after its removal. Researchers will analyze data from different monitoring techniques and assess their ability to predict fluid responsiveness. The primary outcome focuses on agreement between cardiac output measurements using passive leg raising. Safety and diagnostic performance will also be monitored throughout the treatment period.

Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"