Comparing Isolated Ultrafiltration and Conventional Hemodialysis in Adults with End Stage Kidney Disease Evaluating Effects on Heart and Blood Vessel Stability During Dialysis

What this Trial Is About

Patients with end stage kidney disease undergoing hemodialysis face a high risk of cardiovascular problems and complications such as intradialytic hypotension IDH, which can cause damage to the heart, brain, gastrointestinal system, and dialysis access. This study explores whether isolated ultrafiltration iso-UF, a technique suggested to improve blood flow stability during dialysis, offers benefits compared to conventional hemodialysis. The study is randomized and aims to clarify the effects of iso-UF on hemodynamics and patient outcomes using modern dialysis methods. Participants will receive two treatment sequences one involving sequential hemodialysis where isolated ultrafiltration is performed first followed by standard hemodialysis for eight sessions, then switching to conventional hemodialysis for another eight sessions the other sequence reverses this order. The study seeks to measure changes in peripheral resistance, osmolality, cardiac output, and cardiac power index, as well as to assess dialysis quality and duration. Throughout the study, researchers will monitor the total peripheral resistance index over up to eight weeks. Participants will undergo dialysis sessions according to the study schedule while being assessed for hemodynamic stability and dialysis effectiveness. The study includes detailed cardiovascular monitoring to understand how the different dialysis methods impact blood flow and patient health, with safety and dialysis quality closely followed during the trial.

Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis