Study of Heparin-binding Protein and Lung Edema in ICU Patients Using PiCCO Monitoring to Explore Their Relationship with Lung Vascular Permeability

What this Trial Is About

Researchers are investigating the link between lung swelling lung edema and a protein called Heparin-binding Protein HBP in patients in intensive care units ICU. The study focuses on whether the levels of HBP in blood relate to lung blood vessel leakage and the amount of fluid in the lungs. It also looks at how HBP levels connect to the total fluid balance in the body. This observational study involves adult ICU patients monitored with a special device called PiCCO that measures lung fluid and blood flow. The study collects blood samples three times daily over up to three days while patients are monitored with the PiCCO system, which uses a technique called transpulmonary thermodilution to assess lung water and blood volumes. There are no additional treatments given as part of the study it only observes the natural course and measurements in these patients. The PiCCO device requires a central venous line and an arterial catheter and needs regular calibrations during the study period. Participants will have blood samples taken alongside the PiCCO calibrations, and data about lung water, blood volume, and fluid balance will be recorded. Researchers will analyze the relationship between HBP levels and pulmonary vascular permeability index PVPI, which indicates lung vessel leakage, as well as fluid balance. The study lasts while PiCCO monitoring continues, up to three days, with data kept confidential and handled according to privacy regulations. Any clinical findings from monitoring will be managed by the usual ICU care team without influence from the study.

Heparin-binding Protein and Lungedema in ICU Patients.