Actively Recruiting
Hepcidin and Glucose Metabolism
Led by Swiss Federal Institute of Technology · Updated on 2025-05-22
30
Participants Needed
1
Research Sites
339 weeks
Total Duration
On this page
Sponsors
S
Swiss Federal Institute of Technology
Lead Sponsor
U
University Hospital, Zürich
Collaborating Sponsor
AI-Summary
What this Trial Is About
Gestational diabetes mellitus (GDM), defined as hyperglycemia with blood glucose values above normal but below those diagnostic of DM, and iron deficiency (ID) with or without anemia (IDA) are common during pregnancy. Both disease patterns are associated with an increased risk of complications during pregnancy and at delivery and may have a variety of negative effects on different aspects of child development. Thus, GDM and ID/IDA during pregnancy should be prevented. Whether iron supplementation with high oral doses acutely increases hepcidin during pregnancy, and whether this acute iron-induced increase in hepcidin decreases insulin sensitivity, is uncertain.
CONDITIONS
Official Title
Hepcidin and Glucose Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women between 24 and 28 weeks of pregnancy
- Pre-pregnancy body mass index (BMI) less than 27.5 kg/m2
- Singleton pregnancy
- Hemoglobin level greater than 8.0 g/dl
- Willing to either avoid iron supplements for 14 days but receive iron during 4 study days or take the Burgerstein Schwangerschaft & Stillzeit multivitamin containing 30 mg iron daily for 14 days
You will not qualify if you...
- Received an iron infusion in the past 6 months
- Severely anemic with hemoglobin below 8.0 g/dl
- Presence of acute or chronic disease
- Use of long-term medication
- Medical conditions affecting iron metabolism
- Smoking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Human Nutrition Laboratory ETH Zurich
Zurich, Switzerland, 8092
Actively Recruiting
Research Team
N
Nicole U Stoffel, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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