Hospital-Level Care at Home for Acutely Ill Adults: A Randomized Controlled Trial.
David M Levine, Kei Ouchi, Bonnie Blanchfield...
https://pubmed.ncbi.nlm.nih.gov/31842232/Actively Recruiting
Led by Massachusetts General Hospital · Updated on 2025-07-24
30
Participants Needed
2
Research Sites
N/A
Total Duration
Researchers are evaluating a home healthcare program for adults with advanced liver disease, including cirrhosis. This pilot trial aims to provide hospital-level care in the patients home to support those with serious liver conditions like ascites, hepatic hydrothorax, or hepatic encephalopathy. The study is sponsored by Massachusetts General Hospital and focuses on improving care for patients who typically require hospital treatment. The intervention consists of a Hepatology Home Hospital program where patients report symptoms and vital signs from home. This triggers phone calls or home visits as needed, ensuring continuous communication with hepatology clinicians to manage care effectively outside the hospital. This approach allows patients to receive specialized liver disease management while staying at home. Participants will be monitored for up to 18 months, focusing primarily on the rate of care escalation. Additional outcomes include patient experience, adverse events, and acceptability of the home care approach over time. The study involves regular assessments and communication to track health status and safety during the home hospital care period.
CONDITIONS
HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
N
Nneka Ufere, MD, MSCE
W
William Munroe, BA
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Massachusetts General Hospital
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Hepatology Home Hospital (trial) | Standard Outpatient Decompensated Cirrhosis Care |
|---|---|---|
| What it is | An investigational hospital-at-home service providing inpatient-level cirrhosis care at home via symptom and vital monitoring, home visits, and hepatology clinician contact | Ongoing outpatient management of decompensated cirrhosis including medical therapy for ascites, encephalopathy, and routine follow-up |
| Role in trial | Single-group intervention being evaluated for feasibility and outcomes | Not evaluated within this trial, provided as external context |
| Primary use | To deliver hospital-level care at home for patients with decompensated cirrhosis | To manage decompensated cirrhosis complications through clinic-based care |
| How it is performed | Delivered at home with symptom and vital sign monitoring, triggered telephone outreach, home visits, and coordination with hepatology clinicians | Provided in outpatient clinics through medications and routine clinical follow-up |
| Evidence status | Feasibility being assessed in trial; effectiveness not yet established | Guideline-supported outpatient strategies address complications and follow-up |
| Important risks | Not yet established; trial will monitor for adverse events | Risks align with complications of cirrhosis managed in clinic settings |
| Important limitations | An early pilot being evaluated for feasibility; lack of comparative effectiveness data | Outpatient care may not prevent hospital readmissions or allow intensive monitoring |
| Patient impact | Potential to reduce need for inpatient hospitalization and improve patient-centered care, but yet to be demonstrated | Supports management of cirrhosis complications in a clinic-based setting |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
screening and enrollment visit
Duration - Up to 90 days
Participants receive hospital-level hepatology care in their home, including monitoring of symptoms and vital signs, with phone calls and home visits as needed to maintain continuity of care.
Regular home visits and phone calls as part of care
Duration - Up to 18 months
Participants are monitored for escalation events and acceptability of the home hospital intervention over an extended period.
Periodic assessments depending on participant status
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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David M Levine, Kei Ouchi, Bonnie Blanchfield...
https://pubmed.ncbi.nlm.nih.gov/31842232/Olivia Kahn-Boesel, Henry Mitchell, Lucinda Li...
https://pubmed.ncbi.nlm.nih.gov/38466464/Massachusetts General Hospital
Lead Sponsor