Actively Recruiting
Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men
Led by University of Colorado, Denver · Updated on 2025-06-05
242
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of the proposed study is to understand the reasons for the variability in aerobic exercise (AE) training benefits on the vasculature in middle-age and older (MA/O) adults, including differences between men and women. To achieve this goal, a mechanistic randomized controlled (RCT) will be conducted, in which adults are randomized to 12-weeks intervention of AE or no-exercise Control. Our overall hypothesis is that the exercise response variation in vascular benefits is related to age and sex differences in the biological changes underlying vascular aging and/or the molecular transducers (i.e., circulating molecules) that communicate and coordinate the effects of AE on the vasculature in the periphery and brain. Because this is a mechanistic trial, the overall goal is not a single health-related outcome. Rather, the goal is to advance our understanding of the molecular signals and pathways underlying the systemic and local effects of AE on vascular health that may explain the variability in AE responses with age and sex. This knowledge will allow for the development of personalized age- and sex-specific AE recommendations, and/or provide insights into molecular targets that can be manipulated to enhance and/or mimic exercise in non-responders or in persons unable to exercise.
CONDITIONS
Official Title
Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide consent
- Man or woman 18 years or older
- Willing to be randomized to an exercise or control intervention
- No orthopedic limitations preventing treadmill or cycling exercise
- No use of hormone therapy in postmenopausal women or men (hormonal contraceptives allowed in premenopausal women)
- Healthy based on medical history, physical exam, blood tests, and ECG at rest and during graded exercise test
- Sedentary or recreationally active with less than 2 days per week of vigorous activity
- No use of medications affecting cardiovascular function
- No use of vitamins, supplements, or anti-inflammatory medications, or willing to stop one month before and during the study
You will not qualify if you...
- Contraindications to aerobic exercise
- Diabetes or fasting glucose over 126 mg/dL
- Resting blood pressure 140/90 mmHg or higher
- Current or past cancer other than skin cancer
- Preexisting or active heart, kidney, or liver disease
- History of stomach ulcers, bleeding, epilepsy, nervous system or seizure disorders
- Active or chronic infections
- Abnormal resting ECG or signs of heart ischemia during exercise test
- Thyroid dysfunction with TSH below 0.5 or above 5 mU/L unless medically treated for at least 3 months
- Smoking or tobacco use
- Alcohol consumption over 14 drinks per week
- Body mass index over 39 kg/m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
K
Kerrie Moreau, PhD
CONTACT
C
Claire Cox
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here