Actively Recruiting
HFNC Compared With Facial Mask in Patients With Chest Trauma Patients
Led by National Taiwan University Hospital · Updated on 2025-09-08
100
Participants Needed
2
Research Sites
244 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Guidelines for noninvasive ventilation (NIV) recommend continuous positive airway pressure in patients with thoracic trauma who remain hypoxic . However, no any suggestion was applied for high flow nasal cannula (HFNC). Therefore, Our aim was to determine whether HFNC reduces intubation in severe trauma-related hypoxemia.
CONDITIONS
Official Title
HFNC Compared With Facial Mask in Patients With Chest Trauma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with chest trauma within 72 hours despite receiving standard nasal cannula oxygen therapy at 10 L/min or more
- Severe hypoxemic respiratory failure with arterial oxygen level (PaO2)/fraction of inspired oxygen (FiO2) less than 300 mmHg
- Respiratory rate over 25 breaths per minute with difficulty breathing or respiratory distress
- PaCO2 of 45 mmHg or higher
- For patients requiring emergency surgery with intubation, included at start of post-extubation period 72 hours after extubation
You will not qualify if you...
- Glasgow Coma Scale less than 8 or severe brain injury
- Contraindications to non-invasive ventilation such as acute gastrointestinal bleeding, upper airway obstruction, or hemodynamic instability
- Facial trauma involving skull base fractures, facial bone fractures, or orbital floor fractures
- Severe injuries involving the nasal sinuses
- Cervical spine injuries
- Increased intracranial pressure
- Facial, nasal, or airway abnormalities or surgery preventing use of nasal cannula
- Patients after upper airway surgery
- Unable to clearly express willingness to sign informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Department of Traumatology, National Taiwain University Hospital
Taipei, Taipei, Taiwan, 10002
Actively Recruiting
2
NTUH Hsin-Chu Branch; NTUH Yun-Lin Branch
Taipei, Taiwan, Taiwan, 100; 300; 640; 280
Actively Recruiting
Research Team
H
Hsien-Chi Liao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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