Actively Recruiting
The HIEnome Study: Genome Sequencing for Perinatal HIE
Led by Baylor College of Medicine · Updated on 2025-10-01
25
Participants Needed
2
Research Sites
110 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenatal or perinatal hypoxic-ischemic injury. Emerging evidence suggests that genetic conditions are frequently identified in cases of perinatal HIE; however, it is unclear which neonates with this diagnosis warrant genetic testing. This study will offer clinical genome sequencing to neonates with HIE who are undergoing total body cooling (therapeutic hypothermia) and their parents.
CONDITIONS
Official Title
The HIEnome Study: Genome Sequencing for Perinatal HIE
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Delivery at 35 weeks 0 days gestation or later
- Diagnosed with moderate or severe hypoxic-ischemic encephalopathy (HIE), or HIE with seizures
- Undergoing total body cooling (therapeutic hypothermia)
- Able to provide blood or buccal samples during birth hospitalization
- Admitted to Texas Children's Hospital Main, West, or Woodlands neonatal intensive care units
You will not qualify if you...
- Parents or family not willing to allow participation
- Inability to collect sufficient neonatal blood samples (buccal swab may be used as a backup in some cases)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
2
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
C
Christian Parobek, MD, PhD
CONTACT
S
Seema Lalani, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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