Actively Recruiting
HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids
Led by Chinese University of Hong Kong · Updated on 2026-03-27
112
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if High-Intensity Focused Ultrasound (HIFU) is as effective as myomectomy for treating symptomatic uterine fibroids in women aged 18 to 50. The main questions it aims to answer are: Is HIFU as effective as myomectomy in improving quality of life for women with uterine fibroids? How do the recovery times and complications compare between HIFU and myomectomy? Researchers will compare the outcomes of women receiving HIFU treatment to those undergoing myomectomy to see if HIFU offers similar or better results with fewer complications. Participants will: Undergo an initial medical assessment, including ultrasounds and blood tests. Receive either HIFU treatment or myomectomy based on random assignment. Complete questionnaires about their symptoms and quality of life before treatment and at follow-up visits (3 and 6 months post-treatment). Be monitored for any complications and recovery progress during follow-up.
CONDITIONS
Official Title
HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 50 years
- Pre or peri menopausal with FSH less than 25 mIU/ml
- Body mass index under 33 kg/m2 or abdominal wall thickness under 5 cm
- Uterine size 18 weeks or less by physical exam
- Dominant intramural fibroid 3 to 10 cm in size on imaging
- Symptomatic fibroids causing heavy bleeding, pressure, or pelvic pain
- Willing and able to give informed consent
You will not qualify if you...
- Other pelvic masses such as endometriosis, abnormal adnexal mass, ovarian tumor, or pelvic inflammatory disease
- Morbid obesity
- Unable to lie prone for more than 2 hours
- Extensive abdominal scar on the acoustic channel
- Pregnancy, lactation, or menopause
- Uterine premalignant or malignant conditions or unclear pathology
- Rapid fibroid growth (doubling in size within 6 months)
- History or current blood clots or stroke
- Blood clotting problems or use of blood thinning medications
- History of pelvic radiation
- Large pedunculated submucosal or subserosal fibroid (5 cm or larger) with small stalk
- Cervical or broad ligament fibroids
- Cannot undergo MRI due to claustrophobia or implanted metal device
- Co-existing adenomyosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
S
Shing Chee Chan
CONTACT
L
LAI LOI LEE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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