Actively Recruiting
High Dimensional Analysis of Immune Cells Using scRNA-seq in Pediatric Patients With Allergic Reactions to Neuromuscular Blockers
Led by Seoul National University Hospital · Updated on 2024-11-29
294
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying immune cells in children aged 2 to 18 who are undergoing general anesthesia and surgery with the neuromuscular blocker rocuronium. The goal is to use single-cell RNA sequencing to analyze immune cells, especially T lymphocytes, in those who might have allergic reactions to this medication. This observational study focuses on understanding immune responses in pediatric patients during such surgeries. The study involves observing pediatric patients expected to receive rocuronium during general anesthesia. There are no drug treatments or interventions being tested directly; instead, blood samples will be collected during surgery to perform transcriptomic analysis of immune cells. The primary outcome is to analyze the transcriptomic profile of T lymphocytes by RNA sequencing until the end of surgery, typically up to 12 hours after the first dose of rocuronium. Participants will be monitored during their surgical procedure with blood samples taken for laboratory analysis. No additional treatments or interventions are administered as part of the study. Researchers will assess immune cell profiles through RNA sequencing to better understand allergic reactions linked to neuromuscular blockers. The study is led by Seoul National University Hospital and is expected to continue until December 2026.
CONDITIONS
Brief Title
High Dimensional Analysis of Immune Cells in Pediatric Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric patients between the ages of 2 and 18 undergoing general anesthesia and surgery using the neuromuscular blocker, rocuronium.
You will not qualify if you...
- Patients who have received immunomodulators, immunosuppressants, etc.
- Patients with autoimmune diseases such as rheumatoid arthritis, lupus, or Behcet's disease.
- Patients who regularly take, or have taken within 4 weeks, medications that may affect the immune system such as oral steroids or anti-inflammatories.
- Other cases where the Principal Investigator determines that it is difficult to conduct the study.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 hours during surgery
Participants undergo analysis of immune cells using RNA sequencing during surgery.
1 visit (in-person during surgery)
Trial Site Locations
Total: 1 location
1
Seoul National University Hospital
Seoul, South Korea
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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