Actively Recruiting
High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
Led by Rigshospitalet, Denmark · Updated on 2026-01-07
80
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy. The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
CONDITIONS
Official Title
High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years or older
- Able to understand written and spoken Danish
- Pain Catastrophizing Scale (PCS) score of 20 or higher
- Signed written informed consent form
- Planned for elective video-assisted thoracoscopic surgery (VATS) lobectomy or segmentectomy
You will not qualify if you...
- Current systemic glucocorticoid or other immunosuppressive therapy (excluding inhaled steroids)
- Diabetes requiring insulin treatment
- Pregnant or breastfeeding
- Known allergies to Dexamethasone
- Mental disabilities affecting consent or data validity
- Diagnosed schizophrenia, active psychosis, bipolar disorder, or ongoing treatment with antipsychotic or antidepressant medications
- Altered pain perception due to spinal cord or brain injuries, severe polyneuropathies, or neurological disorders
- Regular opioid medication use
- Reoperation needed within first two postoperative days
- Conversion to non-VATS lobectomy/segmentectomy surgery during procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department for Cardiothoracic Surgery, Rigshospitalet
Copenhagen, Copenhagen, Denmark, 2100
Actively Recruiting
Research Team
L
Lasse Visby, Medical Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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