Actively Recruiting
Treatment Study Comparing High-Dose Dual Therapy and Minocycline-Containing Quadruple Therapy for Helicobacter Pylori Infection in Adults Aged 18 to 70
Led by Shanghai Jiao Tong University School of Medicine · Updated on 2024-12-30
200
Participants Needed
10
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating treatment options for patients infected with Helicobacter pylori HP, a common stomach infection. This prospective, multicenter study enrolls 200 patients who test positive for HP through rapid urease tests or 13C urea breath tests. The study aims to assess the success rate of HP eradication, side effects, patient compliance, antibiotic resistance, and how these factors impact treatment outcomes. Participants will receive one of two experimental treatments a high-dose dual therapy consisting of Vonoprazan, a potassium competitive acid blocker, and Amoxicillin, an antibiotic or a minocycline-containing quadruple therapy including Bismuth Potassium Citrate for stomach protection, along with Minocycline and Metronidazole antibiotics. Patients will undergo HP culture and drug sensitivity tests before treatment. The study is non-randomized and does not use blinding. Throughout the study, patients will be monitored for HP eradication six weeks after finishing therapy. Researchers will also track adverse effects and treatment compliance within seven days following therapy completion. Participation involves informed consent and ongoing assessments to evaluate treatment effectiveness and safety. The total participation period extends at least six weeks after therapy to assess outcomes and side effects.
CONDITIONS
Brief Title
High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection
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