Actively Recruiting
High Dose Oral Omeprazole in High Risk UGIB
Led by King Chulalongkorn Memorial Hospital · Updated on 2025-09-18
128
Participants Needed
2
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding. Intravenous PPI is recommended as a standard treatment. In the past, there were many trials showing the efficacy of high-dose oral PPI after endoscopic hemostasis but most were industrial sponsor which assessing an expensive PPI. Moreover, the number of patients in those studies were insufficient to confirm a non-inferiority outcome in term of rebleeding by using oral PPI. This study will evaluate a high-dose, local-made PPI (omeprazole) in peptic ulcer treatment after successful endoscopic hemostasis compared to standard IV PPI continuous drip in term of rebleeding, as well as 24-hour gastric pH monitoring.
CONDITIONS
Official Title
High Dose Oral Omeprazole in High Risk UGIB
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with peptic ulcer bleeding showing Forrest classification Ia (spurting hemorrhage), IIa (oozing hemorrhage), or Ib (non-bleeding visible vessel) on endoscopy
- Age over 18 years old
You will not qualify if you...
- Decline to participate
- Pregnancy or breastfeeding
- Low risk peptic ulcer bleeding such as clean base ulcer or flat pigmented spot
- Non-peptic ulcer bleeding causes like erosive gastritis/duodenitis, Mallory Weiss tear, esophageal/gastric/duodenal varices, vascular lesions (e.g., Dieulafoy), or malignant ulcer
- Bleeding disorders
- Terminal stage cancer
- End-stage renal disease on hemodialysis
- Decompensated liver cirrhosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
King Chulalongkorn Memorial Hospital
Pathum Wan, Bangkok, Thailand, 10330
Actively Recruiting
2
Surin Hospital
Surin, Thailand, 32000
Actively Recruiting
Research Team
R
Rapat Pittayanon, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here