Actively Recruiting
High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)
Led by H. Lee Moffitt Cancer Center and Research Institute · Updated on 2026-02-09
54
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate the feasibility and acceptability of a dietary intervention (FEED-FF) that includes fermented foods (FF), among locally advanced rectal cancer patients and non-small cell lung cancer (NSCLC) patients, and to explore whether this diet can improve outcomes in rectal cancer patients receiving chemoradiation and NSCLC patients receiving immunotherapy.
CONDITIONS
Official Title
High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Diagnosed with locally advanced rectal cancer (Stage II-III) and will undergo neoadjuvant chemoradiation at Moffitt Cancer Center
- Diagnosed with stage II-IV non-small cell lung cancer and will undergo immunotherapy with immune checkpoint inhibitors (+/- chemotherapy or other treatment) at Moffitt Cancer Center
- Able to pick up fermented foods once weekly at Moffitt Cancer Center
- Able to speak and read English
- Able to consume foods orally
- Able to provide informed consent
You will not qualify if you...
- Antibiotic use within 1 month prior to baseline
- Currently using probiotics and unwilling to stop probiotic use
- Previous surgery, immunotherapy, chemotherapy, or radiation for colon or rectal tumor
- Clinician-confirmed inflammatory bowel conditions (e.g., ulcerative colitis, Crohn's disease)
- Infectious disease diagnosed less than 1 month prior to baseline
- Already consuming 2 or more servings of fermented foods per day
- Previously diagnosed with a mast cell disorder or histamine allergy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
Research Team
S
Stephanie Hogue
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here