Actively Recruiting
High-field MR Imaging in Migraine, Visual Snow and Epilepsy
Led by University of Zurich · Updated on 2025-10-08
200
Participants Needed
2
Research Sites
69 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
B
Balgrist University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine. The pathobiology is understudied, but it is believed that both etiologies results from brain networks changes. A clinical certified 7T Terra Siemens scanner will be employed to assess in all participants (including healthy controls) how the microstructure differs in disease specific areas. Patients will further be clinically assessed as well as undergo questionnaires. Migraine is also a common comorbidity to visual snow syndrom and has been shown to impact similar brain regions. However, the pathophysiology is still understudied and a better understanding of the two diseases is needed.
CONDITIONS
Official Title
High-field MR Imaging in Migraine, Visual Snow and Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to read and sign the informed consent form
- Stable migraine preventive medication for at least 2 months before MRI
- Diagnosis of migraine (with or without aura, episodic or chronic) confirmed by clinical interview and questionnaire at least 8 weeks before MRI, with at least 2 migraine attacks per month
- Diagnosis of drug-resistant epilepsy according to ILAE criteria
- Diagnosis of Visual Snow Syndrome
- Healthy participants must have no migraine or epilepsy and be able to read and sign the informed consent form
You will not qualify if you...
- Botox treatment for migraine within 4 months before baseline or during the study
- Pregnant or breastfeeding women
- Women planning to become pregnant during the trial
- Women with bilateral ovariectomy, with or without hysterectomy, and postmenopausal women (>2 years) not considered childbearing
- Significant other medical conditions such as kidney, liver, or cardiovascular disease
- Known or suspected noncompliance, drug or alcohol abuse
- Inability to follow study procedures due to language, mental illness, or dementia
- Prior participation in this clinical trial
- Investigator, their family, employees, or dependent persons
- Presence of metallic objects in the body (e.g., splinters, MR incompatible implants)
- Pacemaker
- Claustrophobia
- Obesity with body mass index over 35 kg/m2
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Klinik Lengg
Zurich, Switzerland, 8008
Actively Recruiting
2
University Hospital Zurich
Zurich, Switzerland, 8091
Actively Recruiting
Research Team
L
Lynn Farner, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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