Actively Recruiting
High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema
Led by Third Military Medical University · Updated on 2026-05-04
200
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE).
CONDITIONS
Official Title
High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Symptoms of HAPE (like difficulty breathing at rest, cough, or exercise intolerance) started within 7 days of reaching high altitude (≥2500m)
- Diagnosis of HAPE requiring at least two symptoms (dyspnea at rest, cough, weakness/decreased exercise performance, or chest tightness/congestion) and two clinical signs (rales or wheezing in at least one lung field, central cyanosis, tachypnea, or tachycardia)
- Radiographic evidence of pulmonary edema on chest X-ray or CT
- Refusal or inability to descend immediately at presentation
- Ability and willingness to provide written informed consent
You will not qualify if you...
- Known or confirmed pregnancy
- Need for emergency intubation due to cardiac or respiratory arrest, severe hypoxia, or impaired consciousness
- Pulmonary edema or low oxygen levels caused by other conditions like cardiogenic edema, sepsis, COPD, pneumothorax, pleural effusion, or chest trauma
- Glasgow Coma Scale score 12 or less
- PaCO2 greater than 55 mmHg
- Presence of high-altitude cerebral edema
- Use of respiratory support other than conventional oxygen therapy before admission
- Contraindications to conventional or nasal oxygen therapy
- Severe medical conditions or abnormal lab results that may risk safety or study completion
- Participation in other clinical trials
- Refusal to sign informed consent form
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NO.953 Hospital
Xigazê, Tibet, China, 857000
Actively Recruiting
Research Team
Y
Yiding Li, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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