Actively Recruiting
High Flow Nasal Oxygen for Exacerbation COPD
Led by Franciscus Gasthuis · Updated on 2025-08-21
40
Participants Needed
4
Research Sites
133 weeks
Total Duration
On this page
Sponsors
F
Franciscus Gasthuis
Lead Sponsor
R
Reinier de Graaf Groep
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this pilot study the feasibility of performing a larger trial to study the non-inferiority of High Flow Nasal Oxygen compared to non-invasive ventilation in patients with acute acidotic hypercapnic exacerbation of COPD wil be investigated
CONDITIONS
Official Title
High Flow Nasal Oxygen for Exacerbation COPD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Known chronic obstructive pulmonary disease
- Acute hypercapnic exacerbation with PaCO2 >45 mmHg or >6.0 kPa and pH 7.20-7.35
- Age over 40 years
You will not qualify if you...
- Asthma
- Immediate need for intubation based on physician judgment
- Unable to use either HFNO or NIV
- Unable to give informed consent due to cognitive impairment or psychiatric disease
- Established or indicated home NIV or CPAP use
- Expected death soon
- Other respiratory or acute diseases affecting treatment efficacy (heart infarction, cardiogenic lung edema, massive pulmonary embolism)
- Severe acute conditions (hemodynamic instability, reduced consciousness, severe intoxication)
- Tracheostomy
- Participation in other interventional trials
- Unable to admit to ICU or monitored ward
- Previous objection to research participation
- Bicarbonate level below 20 mmol/L
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Reinier de Graaf
Delft, Netherlands
Not Yet Recruiting
2
Franciscus Gasthuis & Vlietland
Rotterdam, Netherlands
Actively Recruiting
3
Ikazia
Rotterdam, Netherlands
Not Yet Recruiting
4
Haaglanden Medisch Centrum
The Hague, Netherlands
Not Yet Recruiting
Research Team
D
Dorien Kiers, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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