Physiologic Effects of High-Flow Nasal Cannula Oxygen in Critical Care Subjects.
Frederic Vargas, Mélanie Saint-Leger, Alexandre Boyer...
https://pubmed.ncbi.nlm.nih.gov/25944940Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID06879600
Research on Pre-Anesthetic Blood Oxygenation Effect of High-Flow Nasal Oxygen for Emergency Surgery Patients With Full Stomachs
Led by Nguyen Dang Thu · Updated on 2025-03-17
200
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
Sponsors
N
Nguyen Dang Thu
Lead Sponsor
H
Hanoi Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the use of high-flow nasal oxygen (HFNO) to improve preoxygenation before and during anesthesia induction in adult emergency surgery patients with full stomachs. These patients face a high risk of regurgitation and aspiration under general anesthesia and are vulnerable to low oxygen levels during induction. HFNO, commonly used in intensive care units, offers benefits such as continuous positive airway pressure and better oxygen delivery, which may enhance safety during anesthesia induction. In this randomized controlled trial, adult patients undergoing emergency surgery are assigned to one of two groups. The intervention group receives HFNO preoxygenation with heated, humidified pure oxygen at 60 L/min for 3 minutes using nasal cannulae suited to their nostril size. HFNO continues during intubation to provide continuous or apneic oxygenation. The control group receives preoxygenation with a traditional face mask delivering 100% oxygen at 10 L/min for 3 minutes, removed after induction to allow intubation. Rapid sequence induction uses standard medications with cricoid pressure until intubation is complete. Participants are monitored throughout the perioperative period with measurements including arterial oxygen levels (PaO2), oxygen saturation changes during preoxygenation, and episodes of desaturation during intubation. Additional outcomes assessed include carbon dioxide levels, gastric volume, regurgitation and aspiration events, nasal congestion after extubation, and hemodynamic effects. The study collects data during the anesthesia induction and immediately after, aiming to improve oxygenation strategies for this high-risk group.
CONDITIONS
Brief Title
High-Flow Nasal Oxygen for Preoxygenation in Emergency Surgery Patients With Full Stomachs
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Emergency surgical patients at risk of gastric fullness requiring endotracheal intubation.
- Patients aged 18 years or older.
- Health status classified as ASA I or II.
- Mallampati classification I or II.
You will not qualify if you...
- Patients with a predicted difficult airway, facial deformities, or an inability to achieve a proper mask seal.
- Patients with respiratory diseases.
- Pregnant patients.
- Patients allergic to anesthesia or resuscitation drugs.
- Patients who do not consent to participate in the study.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Single day during emergency surgery
Participants undergo preoxygenation before emergency surgery using either high-flow nasal cannula therapy or a traditional facemask. Preoxygenation lasts for 3 minutes, followed immediately by rapid sequence induction and intubation under general anesthesia.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Department of Anesthesia, Phu Tho General Hospital
Viet Tri, Phu Tho, Vietnam, 290000
Actively Recruiting
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Research Team
H
Hong Bui Minh, M.D
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial.
Mickaël Vourc'h, Pierre Asfar, Christelle Volteau...
https://pubmed.ncbi.nlm.nih.gov/25869405Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE): a physiological method of increasing apnoea time in patients with difficult airways.
A Patel, S A R Nouraei
https://pubmed.ncbi.nlm.nih.gov/25388828Optimizing oxygenation and intubation conditions during awake fibre-optic intubation using a high-flow nasal oxygen-delivery system.
S Badiger, M John, R A Fearnley...
https://pubmed.ncbi.nlm.nih.gov/26253608Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) vs. facemask breathing pre-oxygenation for rapid sequence induction in adults: a prospective randomised non-blinded clinical trial.
Å Lodenius, J Piehl, A Östlund...
https://pubmed.ncbi.nlm.nih.gov/29330853High-flow nasal oxygen versus face-mask ventilation for rapid sequence induction in non-elective surgical patients: a randomized controlled trial.
Nguyen Duc Lam, Le Dinh Thanh Son, Tran Minh Phat...
https://pubmed.ncbi.nlm.nih.gov/41620676