Actively Recruiting
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Led by Region Stockholm · Updated on 2025-04-11
150
Participants Needed
1
Research Sites
144 weeks
Total Duration
On this page
Sponsors
R
Region Stockholm
Lead Sponsor
K
Karolinska Institutet
Collaborating Sponsor
AI-Summary
What this Trial Is About
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability. However, it is demonstrated that HFNO (High Flow Nasal Oxygen) for pre and perioxygenation is feasible and, in many situations, prolongs the safe apnoeic period after anaesthesia induction. Previous data of the use of HFNO during intubation of the critically ill is conflicting. With the new device Optiflow Switch, which allow its combination with NIV or tight facemask with perioxygenation, we aim to evaluate whether this could reduce intubation-related hypoxaemia and other adverse events. The general purpose of this project is to compare the addition of Optiflow Switch for pre- and perioxygenation to traditional preoxygenation using a tight-fitting mask or NIV during intubation in adult intensive care patients in a prospective before-and-after study design.
CONDITIONS
Official Title
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult, 18 years old or older
- Intensive care patients requiring tracheal intubation for any reason
You will not qualify if you...
- Skull or facial injuries preventing nasal cannula use, as determined by the intensivist
- Pregnancy
- Total nasal obstruction
- Deemed unsuitable for other reasons than those listed
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Karolinska University Hospital
Stockholm, Stockholm County, Sweden, 17176
Actively Recruiting
Research Team
I
Ida-Maria Forsberg, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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