Actively Recruiting
High-Frequency Oscillation Ventilation Versus Conventional Mechanical Ventilation in Very Preterm Infants With Perinatal Acute Respiratory Distress Syndrome: Multicenters Randomized Controlled, Superiority Trial
Led by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Updated on 2025-10-06
400
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
Sponsors
D
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Lead Sponsor
C
Children's Hospital of Chongqing Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Bronchopulmonary dysplasia (BPD) is a complex disorder and remains the most common complication in very preterm infants. Its incidence is increased with gestational age from 95.5% among infants born at 22 weeks' gestation to 22.2% among those born at 29 weeks' gestation. BPD is associated with the increased risks of delayed neurodevelopment and pulmonary impairment. High incidences of BPD and morbidities indicate inadequacy of current management guidelines of BPD.3 Caffeine reduces the development of BPD by lowering the duration of intubation.4 How to further reduce the risk of BPD and the duration of invasive ventilation remain the key focus for neonatologists.
CONDITIONS
Official Title
High-Frequency Oscillation Ventilation Versus Conventional Mechanical Ventilation in Very Preterm Infants With Perinatal Acute Respiratory Distress Syndrome: Multicenters Randomized Controlled, Superiority Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Gestational age between 24 weeks 0 days and 31 weeks 6 days
- Preterm infants admitted to NICU within 1 hour after birth with perinatal ARDS diagnosed by Montreux guidelines
- Stable on conventional mechanical ventilation before randomization with specific respiratory and blood gas parameters
- Hematocrit level above 35%
You will not qualify if you...
- Parents or guardians decline participation
- Major congenital anomalies or chromosomal abnormalities
- Need for surgery or grade higher than 2nd intraventricular hemorrhage before randomization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400042
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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