Actively Recruiting
High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia
Led by University of Utah · Updated on 2025-04-04
50
Participants Needed
2
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to conduct a prospective study of all congenital diaphragmatic hernia (CDH) neonates managed at the University of Utah newborn intensive care unit (NICU) and Primary Children's Hospital NICU that required mechanical ventilation at birth. As both high frequency jet ventilation (HFJV) and high frequency oscillatory ventilation (HFOV) are standard approaches to ventilatory support of all neonates including CDH, CDH infants will be randomized at the time of birth or admission to either HFJV or HFOV as initial ventilator mode, stratified by position of the liver in the abdomen or thorax (if known) by 24 hours of age. Measures of oxygenation, ventilation and hemodynamics of the CDH cohort managed on HFOV compared to those on HFJV.
CONDITIONS
Official Title
High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admitted to either the University of Utah and/or Primary Children's Hospital NICU within 24 hours of birth
- Requires mechanical ventilation
- Has an umbilical arterial line or peripheral arterial line in place
- Signed consent has been obtained
- Infant is less than or equal to 24 hours of age
You will not qualify if you...
- Presence of severe anomalies such as chromosomal abnormalities or major congenital anomalies including cardiac, central nervous system, and syndromes
- Diagnosis made after 24 hours of life
- Unable to obtain consent for participation
- Unable to be randomized within 24 hours of life
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Primary Children's Hospital
Salt Lake City, Utah, United States, 84113
Actively Recruiting
2
University Hospital
Salt Lake City, Utah, United States, 84132
Actively Recruiting
Research Team
M
Michelle Yang, MD
CONTACT
C
Carrie Rau
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here