Actively Recruiting
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
Led by University of Alabama at Birmingham · Updated on 2025-08-08
60
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognitive impairments (Aim 1) to a greater extent than continuous moderate exercise. Additionally, investigator will seek to identify barriers to engagement in exercise and the participants' perceptions of the study and exercise interventions (Aim 2). This study will enroll 60 participants in Birmingham, Alabama. Data collection will occur at each visit, with baseline data collected at the initial visit with a 3-month follow-up occurring following completion of the intervention.
CONDITIONS
Official Title
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 years and older
- Sedentary lifestyle, defined as less than 150 minutes per week of moderate physical activity as assessed by CHAMPS questionnaire
- Neurocognitive impairment as assessed using the BRACE+
- Prescribed HIV antiretroviral therapy for 12 months or more, with no use of older drugs causing mitochondrial toxicity
- Able to speak, read, and write in English
- Willing to participate in all study procedures
You will not qualify if you...
- Diagnosis of mitochondrial disease
- Active substance abuse or factors preventing compliance or safety
- Uncontrolled hypertension, defined as resting blood pressure over 150/90 mmHg
- Chronic kidney disease
- Severe cardiac disease including NYHA Class III or IV heart failure, significant aortic stenosis, history of cardiac arrest, use of cardiac defibrillator, or uncontrolled angina
- Acute myocardial infarction identified by medical history and ECG
- Pulmonary disease requiring supplemental oxygen
- Poorly controlled diabetes
- Neuropsychologically intact
- Orthopedic problems limiting ability to exercise
- Participation in another intervention trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35205
Actively Recruiting
Research Team
R
Raymond Jones, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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